Begin each day with purpose and positivity with the 7 Good Minutes Daily Self-Improvement Podcast, the essential listen for mindful achievers. Tailored for those who strive for personal growth amidst their busy lives, our podcast offers daily guidance in mindfulness, gratitude, and maintaining a positive mindset. Explore a world of transformative ideas and begin your day with the inspiration you need to cultivate a life of awareness, appreciation, and optimism. Subscribe now to ensure you never miss an episode on your journey to a more mindful and positive life.

Success Redefined: How Daily Rituals Transform Your Life

7 Good Minutes

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- Redefining Success: Success isn't just about big achievements and promotions that make headlines. True success can be found in the quality of our daily experience and the consistency of showing up for ourselves through intentional rituals that align with our deepest values.

- Daily Rituals as Votes for Your Future Self: Every morning presents an opportunity to vote for the person you want to become through your daily practices. Choosing meditation over checking your phone is voting for presence over reactivity, while journaling is voting for self-awareness over autopilot living.

- Internal Validation vs. External Metrics: Traditional success metrics often leave us feeling empty because they're based on comparison and scarcity. Personal rituals create an internal scorecard that no one else can manipulate or diminish, freeing you from the need for external validation.

- Transforming Your Relationship with Time: Daily rituals help us become active participants in shaping our days rather than feeling like time is something that happens to us. This shift from passive to active living represents a profound redefinition of success.

- The Power of Simple Practices: Transformative rituals don't need to be elaborate or time-consuming. Success might be as simple as taking three conscious breaths before entering your home, writing down one thing you're grateful for each night, or spending five minutes in silence each morning.

- Compound Effect of Consistent Rituals: Each ritual is a small deposit in the bank account of your well-being. Over time, these deposits compound, creating a wealth of inner resources that no external circumstance can diminish—success that grows from the inside out.
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I’m Jay Shetty host of On Purpose the worlds #1 Mental Health podcast and I’m so grateful you found us. I started this podcast 5 years ago to invite you into conversations and workshops that are designed to help make you happier, healthier and more healed. I believe that when you (yes you) feel seen, heard and understood you’re able to deal with relationship struggles, work challenges and life’s ups and downs with more ease and grace.
I interview experts, celebrities, thought leaders and athletes so that we can grow our mindset, build better habits and uncover a side of them we’ve never seen before. New episodes every Monday and Friday. Your support means the world to me and I don’t take it for granted — click the follow button and leave a review to help us spread the love with On Purpose. I can’t wait for you to listen to your first or 500th episode!

8 Simple Mindset Shifts to Feel Gratitude Even When Your Life Isn’t Where You Want it To Be

On Purpose with Jay Shetty

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- Separate Gratitude from Denial: True gratitude isn't pretending everything is fine while ignoring difficulties. It's acknowledging your struggles while still recognizing things worth appreciating. When you can hold both realities simultaneously, you experience greater resilience and lower depression compared to those who practice toxic positivity. Try using phrases like "even though" to acknowledge both truths - for example, "Even though work is stressful, I'm grateful I'm learning new skills."

- Don't Use Gratitude to Shut Down Emotions: Saying "at least I still have a job" when you're struggling minimizes your feelings and creates guilt. Replace "at least" with "and" - as in "This is hard AND I'm grateful I still have a job." This allows your emotions to coexist rather than competing. Try creating two columns in your journal: "what's hard right now" and "what's still good right now" to visualize both realities.

- Focus on What Remained: When life falls apart, we naturally focus on what was lost. Instead, try noticing what stayed - the friends who checked on you, the parts of yourself that showed up when everything else disappeared. This reminds you that not everything was taken and gives you a foundation to rebuild from. Make a list of three things that didn't leave you this year.

- Practice Gratitude Through Contrast: Rather than comparing yourself to others (which breeds envy), compare yourself to your past self to see your growth. The calm you feel today may have once been chaos; the strength you have now was once just survival mode. Remember that the things you take for granted now were once things you prayed for. This transforms gratitude from competition to self-compassion.

- Implement Micro Gratitude: Throughout your day, take 10-second pauses to notice something good happening right now - the aroma of coffee, sunlight through a window, or the sound of laughter. This brief practice rewires your brain's fear center to recognize safety cues, helping calm anxiety in real time. Feel gratitude physically in your body, noticing where warmth or ease appears.

- Reframe Waiting Seasons: When life isn't where you want it to be, it's easy to resent waiting periods. However, growth seasons rarely look glamorous. Like bamboo spending five years growing roots underground before shooting up, your waiting season is preparing you. Instead of asking "why isn't it happening yet?" ask "who am I becoming while I wait?"

- Borrow Gratitude When You Can't Find Your Own: If you struggle to feel grateful for your own life, witness someone else's joy - a child playing, an old couple laughing, or a friend achieving something. Research shows observing others' gratitude activates the same brain regions as feeling it yourself. Practice saying "I'm happy for them" even when you're hurting. This builds emotional muscle memory and helps you reconnect with joy.

- Thank Your Past Self: Write a thank-you note to the version of you that survived difficult times - the one who showed up when it was hard, who loved people who didn't love back, who held everything together when no one noticed. This practice activates the brain's emotional regulation centers and increases self-worth. Acknowledge that your past self wasn't perfect but did the best they could with what they had.
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The day’s top stories from BBC News. Delivered twice a day on weekdays, daily at weekends.

National Guard member dies after shooting in Washington DC

Global News Podcast

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US National Guard Tragedy Near White House: A shooting near the White House resulted in the death of 20-year-old National Guard member Sarah Beckstrom and critically injured 24-year-old Andrew Wolf. The suspect, Ramanullah Lakamwal, an Afghan national who previously worked with the CIA and was granted asylum in the U.S., was detained at the scene. In response, the Trump administration announced plans to review permanent residency status of people from 19 countries, including Afghanistan.

Israeli Forces Shoot Palestinians in West Bank: Video footage shows Israeli security forces shooting two Palestinians who appeared to have surrendered in Jenin in the occupied West Bank. The men are seen kneeling with at least one raising his shirt to show he was unarmed before being shot when they began to re-enter a building. The Palestinian Authority described it as a "summary execution" while Israeli authorities say the incident is under review.

Hong Kong's Deadliest Fire in Decades: More than 90 people have died in a devastating fire that spread through multiple high-rise apartment buildings in Hong Kong, with hundreds still missing. The fire, which began in buildings undergoing renovation, has prompted a criminal investigation with three construction company executives arrested on suspicion of manslaughter. Questions are being raised about flammable building materials, including bamboo scaffolding and mesh coverings.

Cat Domestication's Grim History: New research led by Oxford University's Professor Gregor Larson reveals that cats were domesticated in Egypt and North Africa, not in the Levant as previously believed. The study indicates that mass sacrifices of cats for religious purposes in ancient Egypt forced them to adapt to breeding in captivity, which was a crucial step toward domestication. This challenges the previous theory that cats became domesticated naturally through hunting mice in grain storage areas.

Kenyan Farmers Win Seed Rights Case: Fourteen Kenyan farmers have successfully overturned a law that prohibited them from saving and sharing seeds from their crops. The restrictive law had favored commercial seed companies and threatened farmers with fines of up to $8,000 or jail time for following traditional seed-saving practices. The court ruling, which came after a three-year legal battle, has been celebrated as a victory for food sovereignty and traditional farming practices.

Putin's Uncompromising Stance on Ukraine: In response to the latest U.S. peace proposal for Ukraine, President Putin has doubled down on his demand that Ukraine surrender territory for any peace deal. He claimed that Russian forces would continue fighting until Ukrainian troops withdraw from territories that Russia claims, and suggested that Kyiv's leadership has lost legitimacy, indicating Moscow is not eager to negotiate with Ukraine's current government.

Snake-Handling Church in Appalachia: One of the last churches in the U.S. where venomous snakes are handled during services, the House of the Lord Jesus in West Virginia, has been documented by Grammy-winning producer Ian Brennan. The practice, based on a literal interpretation of biblical passages about handling serpents without harm, has reportedly led to the deaths of over 100 preachers in the last century. The recordings capture both the intense faith-based practice and the distinctive musical tradition of the region.
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Wichtige Zusammenhänge, überraschende Hintergründe, gründliche Recherchen. Täglich Neues aus Gesundheit und Ökologie, Wissenschaft und Weltgeschehen im Podcast Das Wissen. Manuskripte und weitere Informationen zu den einzelnen Folgen: http://swr.li/daswissen

TikTok-Brain und Doomscrolling – Wie Social Media Jugendlichen schaden

Das Wissen | SWR

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Youth Social Media Usage: Around 25% of 10-17 year-olds spend excessive time on social media platforms like TikTok, Instagram, and WhatsApp. The podcast introduces young people including a 17-year-old girl in Berlin who regularly uses these platforms along with her friends.

"TikTok Brain" Phenomenon: Heavy social media usage can lead to what experts call "TikTok Brain," which is characterized by memory and concentration problems. The constant stream of content tailored by algorithms encourages binge-watching behavior and can negatively impact cognitive development.

Psychological Effects: Social media platforms operate using light signals and notification systems designed to keep users engaged through continuous rewards. For children and adolescents, this can impact their emotional development and their ability to think, feel, and demonstrate empathy (what's known as "theory of mind").

Smartphone Bans in Schools: Some schools in Berlin have implemented smartphone bans, but neurobiologist Martin Korte notes that there's limited scientific evidence regarding the effectiveness of such prohibitions. The issue may simply shift smartphone usage to after-school hours rather than reducing it.

Expert Recommendations: The Leopoldina (German National Academy of Sciences) has published recommendations for protecting children and youth online. Ralf Hertwig, a director at the Max Planck Institute for Human Development in Berlin, suggests age-appropriate usage for 13-16 year-olds while limiting addictive features like endless scrolling.

Regulatory Challenges: The podcast discusses regulatory efforts including the EU's Digital Services Act, but highlights the challenges of effective age verification. Experts hope for better technical solutions while emphasizing that bans alone aren't enough to protect young people.

Balanced Approach Needed: Rather than outright prohibition, experts advocate for a balanced approach that includes education about responsible social media use, appropriate regulations, and greater involvement from platforms in protecting young users' mental health and development.
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Anne-Marie Zanzal, M.Div is the creator and host of Coming Out & Beyond | LGBTQIA+ Stories. She deeply believes that in the hearing of another's story we can often here our own. Her podcast focuses on sharing the coming out stories of the Queer community. . Coming out stories is what connect everyone in the LGBTQIA+ community. These stories are compelling, heartbreaking and inspirational. But this podcast does not stop there. Straight media focuses so much on the coming out part, they often miss the "Beyond." Anne-Marie's guests have created lives of creativity, joy, authenticity and services to their fellow humans.

She started this podcast because she felt the need to normalize exploration of questioning sexuality/gender at all ages, plus visibility is vital to the LGBTQIA+ community. It is never too late to be who we were created to be. Her guests prove that.

Anne-Marie is a graduate of Yale Divinity School, an ordained minister in the progressive United Church of Christ, bereavement counselor, a coming out and divorce coach, conversationalist, spiritual wanderer, later-in-life lesbian, change maker, blogger, author, a northerner living in the south and trying to figure it all out.

Anne-Marie has been featured in print and digital publications including Oprah Magazine, New York Times, BBC, CBC and iNews. She has appeared on numerous podcasts including Two Bottles Deep, Life (Un) Closeted, The Love Fix, Virgin Beauty Bitch, The Late Life Lesbian (YouTube), and many more. You can learn more about Anne-Marie at www.annemariezanzal.com.

❤️The Best Tool For Change? Love! - Part 2

Coming Out + Beyond | LGBTQIA+ Stories

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The Power of Labels in LGBTQ+ Communities: While labels can be useful for identification purposes, they can also create harmful separation between people. David Cunningham explains how naming and separating groups (like "immigrants") makes it easier to judge, hate, or harm others who are seen as different from ourselves.

Viewing Emotions as Temporary Experiences: Emotions are not who we are but experiences we have. David illustrates this by explaining that when emotions like anger or fear pass, we remain - proving that emotions are like clouds passing through the sky of our awareness rather than our core identity.

Redefining Forgiveness: Forgiveness is not about condoning behavior or saying something was acceptable; it's a personal choice about how we want to live. Forgiving means choosing to give love to someone rather than living with resentment, which primarily benefits our own wellbeing.

The Heart's Role in Transformation: David describes practical exercises for working with difficult emotions, like visualizing holding troublesome feelings or people in your hands and bringing them to your heart to dissolve them, or imagining love radiating from your heart into the world.

The Relationship Paradigm Shift: The quality of our life never comes from other people but from who we choose to be. David explains that in relationships, we don't "get" love from others but rather have opportunities to be loving. This understanding transforms how we approach relationships, removing expectations that others should fulfill us.

Acceptance vs. Condoning: Acceptance doesn't mean approving of something but simply acknowledging what is. Similar to accepting that it's raining without saying rain is "good" or "bad," we can accept difficult situations or behaviors without condoning them, allowing us to respond effectively.

Moving Beyond Right/Wrong Thinking: The paradigm of right/wrong and good/bad is made up and doesn't exist in the world objectively. Everyone has their own view, and arguing which view is "right" isn't useful. Instead of focusing on what's right or wrong, we can focus on what works and what doesn't work.

Love Goes to the Capitol Initiative: David shares his initiative to send his book to every member of Congress and his plan to visit the Pennsylvania State Capitol weekly for a year to perform acts of love with different marginalized groups, with no political agenda - just demonstrating love in action.

The Love Footprint Concept: David invites listeners to become conscious of the "love footprint" they leave behind in their daily interactions. Before entering situations, ask yourself what love footprint you want to leave, and afterward, evaluate how you did without judgment.

Practicing Self-Acceptance: When we don't live up to our own standards for loving behavior, David encourages acceptance rather than self-judgment, eliminating the "shoulds" and "shouldn'ts" that lead to unnecessary suffering.
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What does it look like to "be transformed by the renewing of our minds"?  How do we live intentionally for Kingdom impact?  Join co-hosts Heather Brown and Keane Fine every Friday to learn from our guests about how we can grow in Christ and impact the world.

This show is brought to you by TeachBeyond, an international Christian mission organization focused on transformational Christ-centered education serving individuals and communities.

The Myth of Being Perfect | Spiritual Formation with Brian Delamont (Ep. 198)

Transformed & Transformational

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- The Misunderstood Concept of Perfection: The word "perfect" is commonly used in everyday language, but has been misinterpreted in Christian contexts. When Jesus says "be perfect as your heavenly Father is perfect" in Matthew 5:48, He's not demanding flawless behavior but using the Greek word "teleios," which means complete, mature, or fully developed.

- Excellence vs. Perfectionism: TeachBeyond values excellence, which means doing the best possible with available resources and skills, not achieving an impossible standard of perfection. Excellence is contextual and flexible, whereas perfectionism can be crushing, toxic, and create unbearable pressure.

- God's Perfection as Our Refuge: God's perfection isn't about demanding performance but offering protection. In 2 Samuel 22:31, "God's way is perfect... He shields all who take refuge in Him." His perfection becomes our shelter, not our standard of condemnation.

- Complete Commitment vs. Perfect Behavior: In the story of the rich young ruler (Matthew 19:16-22), Jesus wasn't asking for perfect behavior but complete commitment. The young man went away sad because his wealth had greater priority in his life than following Jesus completely.

- Strength in Weakness: Paul explains in 2 Corinthians 12:8-10 that God's power is made perfect (complete) in our weakness. Our limitations and vulnerabilities aren't obstacles to God's work but opportunities for His strength to be displayed. As Paul David Tripp notes, "Our limits and weaknesses are not in the way of what God can do through us, but our denial of limits and our delusions of independent strength are."

- Already Perfect, Being Made Holy: Hebrews 10:14 explains this paradox: "For by one sacrifice he has made perfect forever those who are being made holy." Through Christ's sacrifice, believers are already made perfect (complete) in God's eyes, while simultaneously being made holy through the ongoing work of the Holy Spirit.

- Finding Freedom from Perfectionism: Rather than being trapped in either trying to be perfect or giving up entirely, we can find freedom by anchoring ourselves in God's perfection and completeness. This breaks the myth of perfectionism and allows us to rest in God's acceptance rather than striving for an impossible standard.
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Built to Sell Radio is a weekly podcast for business owners interested in selling a business.  Each week, we ask an entrepreneur who has recently sold a business why they decided to sell their business, what they did right and what mistakes they made through the process of exiting their business.  Built to Sell Radio is the ultimate insider's guide to approaching the most important financial transaction of your life.

Ep 522 The difference between 4x vs.8x EBITDA, Customer Concentration Discounts, PE Re-trades with Eric Wiklendt on this special edition of Inside the Mind of an Acquirer

Built to Sell Radio

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PE Firms Focus on Operational Improvements vs Financial Engineering: Speyside Equity, led by Eric Wicklen, takes a different approach from many PE firms by emphasizing operational expertise rather than financial engineering. The three partners all have C-level operational experience in manufacturing businesses, enabling them to identify improvement opportunities that other buyers might miss. This operational background helps them work effectively with management teams to transform underperforming companies.

Valuation Range of 4-8x EBITDA and Key Factors: Speyside values manufacturing companies between 4-8x adjusted EBITDA. Higher multiples (8x+) are paid for businesses with durable revenue streams and strong growth potential. Lower multiples (around 4x) are applied to companies with customer concentration risks, weaker systems/processes, or requiring significant operational improvement. Customer concentration is particularly impactful - one customer representing 20%+ of EBITDA typically reduces valuation by 1-1.5x.

Conservative Debt Approach Enables Transformation: Unlike many PE firms, Speyside maintains conservative debt levels, capping leverage at around 3x EBITDA. This approach gives management teams breathing room to implement operational improvements without being strangled by debt service. Wicklen notes that excessive debt can be "soul-sucking" for management and prevents necessary investments in transformation.

PE "Retrading" Practices Between LOI and Closing: Some PE firms systematically reduce purchase prices between LOI and closing - sometimes by as much as 25-30%. Speyside aims for minimal retrading (around 5%), typically only when due diligence reveals genuine issues. Wicklen recommends sellers work with good investment bankers who can help manage expectations and bridge gaps between buyers and sellers during negotiations.

The PE Business Model and Performance Requirements: PE firms typically operate on a "2 and 20" model - 2% annual management fee and 20% of investment profits. Wicklen references Warren Buffett's criticism that many PE firms only achieve 2x returns (10% annually before fees), which after fees and taxes delivers investors subpar returns compared to index funds. Successful PE firms need to deliver closer to 3x returns to justify their fees and illiquidity.

Three Key Areas for Operational Improvement: When transforming a business from 10M to 20M EBITDA, Speyside focuses on three main areas: 1) Aligning and incentivizing management teams to ensure everyone is working toward the same goals; 2) Rationalizing revenue portfolios by evaluating product families, customers, and manufacturing plants for profitability; and 3) Optimizing operational footprints, including manufacturing and supply chain, to eliminate inefficiencies.

Dealing with Resistant Management: When implementing changes that might face resistance from existing management, Wicklen emphasizes using data and logic while genuinely understanding the context of previous decisions. He stresses the importance of listening to management's perspectives, as most decisions made previously were logical based on the information available at the time. This approach helps overcome resistance and builds trust with operational teams.

Building a Platform for Growth: Speyside evaluates acquisition targets not just on current performance but on their potential to serve as "platforms" for growth. A good platform business has solid systems, processes and people that enable both organic growth (new products, markets, geographies, channels) and inorganic growth through acquisitions. These characteristics significantly impact valuation, with better platforms commanding higher multiples.

Targeting Companies with "Hair" on the Deal: Speyside specializes in situations other PE firms might avoid - businesses with complex challenges, messy structures, or operational issues. Their experience in structuring deals helps them address situations involving environmental issues, pensions, unique tax needs, or other complications. This specialization often reduces competition in deals after the management presentation phase.

Approach to Seller Rollover Equity: Speyside is flexible on deal structures regarding how much equity sellers roll into the new entity, with the only requirement being that Speyside maintains control. This approach allows them to implement necessary operational improvements while giving sellers the opportunity to participate in the upside from those improvements.

The Importance of Investment Bankers in Transactions: Wicklen emphasizes the value of good investment bankers or business brokers, who perform critical "missionary work" with sellers regarding expectations and serve as relationship counselors during difficult negotiations. They help bridge gaps between buyers and sellers when inevitable disagreements arise during due diligence.
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Real Estate Expert, Shawn Moore, from Vodyssey.com, brings you the Vodyssey's Vacation Rental Revolution Podcast. Discover the best tips, tactics &amp; strategies for growing and scaling your short-term vacation rental portfolio. Discover the difference between traditional short-term vacation rentals and true Lifestyle Assets. Learn from Shawn's 20 years of ups and downs in the Real Estate Investing game. Expert interviews on Acquisition, Legal, Finance, Management &amp; more. All focused on building your Lifestyle Asset portfolio giving you Lifestyle &amp; Financial Freedom starting today.

Connect At https://www.vodyssey.com

Episode 330 - OwnerRez Co-Founder & CEO┃Being The Best Host Makes You The Most Money┃Paul Waldschmidt

Vacation Rental Revolution Podcast

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• Evolution of the Short-Term Rental Software Industry: Paul Waldschmidt, CEO and co-founder of OwnerRez, started in the vacation rental space around 2008 by purchasing a "cabin on the river." As a software engineer, he recognized the lack of quality software for small owner-operators and began developing tools for himself, eventually launching OwnerRez in 2013 with co-founder Chris Hines. The company has grown organically since then, becoming a leading property management system while remaining bootstrapped and profitable.

• The Mom-and-Pop Nature of the STR Industry: Both Paul and Shawn agree that short-term rentals remain largely a "mom-and-pop" industry despite its growth. The unique nature of successful vacation properties makes it difficult for institutional investors to scale efficiently. This creates an ongoing need for software tools designed specifically for independent owners rather than enterprise-level operations.

• Technological Evolution Empowering Small Operators: The rise of platforms like Airbnb, combined with improved technology and automation, has enabled more property owners to manage their rentals independently rather than working with traditional property management companies. OwnerRez has focused on serving these small, independent operators by providing enterprise-level tools at accessible price points.

• Using Data and AI to Improve Hospitality: OwnerRez is leveraging AI and data analysis to help hosts identify patterns in guest satisfaction and communication. Their systems can detect sentiment in guest communications and reviews, helping hosts understand where they might be "dropping the ball" as they scale their operations, ensuring they maintain quality hospitality even as they grow.

• The Importance of Guest Reviews: The podcast highlights the value of proactively soliciting guest reviews. Shawn mentions achieving a 90% review rate compared to the industry average of 10-15% by leveraging reciprocity - leaving guests a 5-star review first, which encourages them to reciprocate. OwnerRez offers an automated 5-star review feature that helps hosts increase their review rates significantly.

• The Value of Flexible Cancellation Policies: Both Paul and Shawn advocate for more flexible cancellation policies, noting that while it might seem counterintuitive, offering generous cancellation terms often leads to more bookings overall, particularly during shoulder seasons and mid-week periods. They've found that the occasional cancellation is offset by the increased volume of bookings from guests who appreciate the flexibility.

• Maximizing Revenue Strategy: Shawn shares that his team discovered they should focus on maximizing revenue during peak seasons rather than trying to fill calendar gaps during shoulder seasons. He notes, "You make your money in the peak season," suggesting that hosts should push prices and optimize their strategy when demand is highest rather than focusing on low-demand periods.

• Recognizing If You're a Good Host: An important insight discussed is the need for self-awareness about whether you're suited to be a host. Not everyone has the personality or desire to manage guest communications and hospitality directly. For many owners, hiring a co-host or property manager might be a better strategy even if it cuts into margins, as it allows them to scale more comfortably and focus on what they do best.

• Industry Outlook: Paul predicts continued growth in the STR industry with some consolidation among technology providers. He believes the fundamental appeal of property ownership combined with hospitality will continue to attract individual investors. The convenience and experience offered by vacation rentals have become mainstream with consumers, suggesting ongoing demand for this accommodation type.

• The Balance Between Automation and Hospitality: A recurring theme throughout the conversation is finding the right balance between leveraging technology for efficiency while maintaining the warm, personal hospitality that makes vacation rentals special. The most successful properties are those that use tools like OwnerRez to handle operations while preserving the unique guest experience.
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Day 332 (Acts 18-19) - Year 7

The Bible Recap

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- Paul's Entrepreneurial Ministry in Corinth: Paul arrives in Corinth during his second missionary journey where he meets Aquila and Priscilla, fellow tent makers who had been forced out of Rome. Paul works as a tent maker during the week and preaches at the synagogue on Saturdays, demonstrating his bi-vocational approach to ministry.

- Shifting Focus to Gentile Converts: After facing rejection from some Jews in Corinth, Paul symbolically shakes out his tunic (similar to Jesus' instruction to shake dust from feet) and redirects his evangelistic efforts toward Gentiles. God encourages Paul in a vision, promising protection and assuring him that many in the city will be saved.

- God's Protection and Paul's Vow: Paul remains in Corinth for a year and a half, and despite accusations from local Jews, the governor dismisses the case against him. During this time, Paul likely takes a Nazarite vow (abstaining from cutting hair and consuming alcohol), setting himself apart as dedicated to God in the midst of Corinth's worldliness.

- Aquila, Priscilla, and Apollos: Paul leaves Aquila and Priscilla in Ephesus, where they meet Apollos, an eloquent teacher who doesn't yet have complete theological understanding. They mentor him, explaining the faith more thoroughly, after which Apollos becomes a valuable asset to the early church.

- The Holy Spirit in Ephesus: In Ephesus, Paul encounters people who had been baptized by John the Baptist but weren't aware of the Holy Spirit. When Paul lays hands on them, they receive the Holy Spirit, speak in tongues, and prophesy, showing the progression from John's baptism to full Christian faith.

- Strategic Ministry and Miraculous Works: After facing resistance in the synagogue, Paul shifts his teaching to Tyrannus Hall for two years. Ephesus' position as a major travel hub allows his teaching to spread throughout Asia. God performs extraordinary miracles through Paul, even using items that had touched him to heal the sick.

- Spiritual Authority Demonstrated: When seven brothers attempt to use Jesus' name as a magic spell to cast out demons without having a relationship with him, the demon overpowers them, highlighting that spiritual authority comes from relationship with Jesus rather than merely invoking his name. This incident leads many to confess sins, renounce dark arts, and embrace the gospel.

- Economic Threats and Civil Unrest: As the gospel spreads, a silversmith who makes statues of false gods becomes concerned about his business. He incites a riot among craftsmen who fear the gospel threatens their livelihood tied to the goddess Artemis. The situation is eventually calmed by the town clerk, who fears Roman intervention.

- God's Sovereign Orchestration: The narrator highlights how God weaves together seemingly unrelated circumstances—from Paul's tent-making skills to the expulsion of Aquila and Priscilla from Rome to the rejection by Jews in Ephesus—to accomplish his purposes in spreading the gospel and building the early church.
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The audio companion to DailyDad.com’s daily email meditations on fatherhood, read by Ryan Holiday. Each daily reading will help you find the wisdom, inner strength, and good humor you need in order to be a great dad. Learn from historical figures and contemporary fathers how to do your most important job. Find more at dailydad.com.&nbsp;

You Can Show Them What It Means

The Daily Dad

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- Be the Model of Generosity: The most effective way to raise generous, kind children who are "the opposite of spoiled" is to model these traits yourself. When parents demonstrate generosity and helpfulness in their own lives, children learn these values through observation and participation.

- Feeding America Campaign: Daily Dad and Daily Stoic are partnering to raise $300,000 for Feeding America, with the first $30,000 already donated. Each dollar provides 10 meals to people facing food insecurity, with the goal of providing 3 million meals total.

- Holidays as an Opportunity: Rather than giving in to materialism during the holiday season, parents can use this time to focus on helping those less fortunate. This creates valuable teaching moments for children about the importance of giving rather than receiving.

- Involve Children in Giving: Bringing children into the process of charitable giving—whether through food drives, donations, or volunteering—helps them experience the joy of generosity firsthand and encourages them to see helping others as exciting and rewarding.

- Current Need for Food Assistance: Recent government shutdowns, federal program cuts, and interruptions in benefits have increased the number of food-insecure families, making donations particularly important right now.

- Raising Kids to Be Problem-Solvers: The ultimate goal is to raise children who aren't just self-sufficient but have "energy and resources left over to help others"—kids who become part of solutions rather than contributing to society's problems.
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Welkom op ons hoofdkanaal! Hier luister je naar alle Goede Gesprekken met Lex Bohlmeijer, de Jesse Frederik Show, al onze voorgelezen verhalen en meer. 

Wil je liever los abonneren? Al onze shows zijn te vinden op een eigen kanaal. 

Word ook lid van De Correspondent voor 9,50 euro per maand, 95 euro per jaar of 180 euro per twee jaar. Je krijgt dan toegang tot het platform met alle verhalen en je steunt onze journalistiek. De Correspondent is afhankelijk van de steun van onze leden. Heel erg bedankt!  www.decorrespondent.nl

Het wonderlijke verhaal van de donkergroene activist die Europees topambtenaar werd

De Correspondent

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- The European Green Deal: The Green Deal was the first major project of the von der Leyen Commission. Launched in December 2019, it represents a coherent and comprehensive plan for Europe's transition to sustainability. It aims to transform various sectors including industry and electricity.

- Shift from Combustion to Electricity: The world has historically relied on burning fossil fuels but is now rapidly transitioning to electricity-based energy systems. This shift represents a significant change in how we power our economies and societies.

- Renewable Energy Expansion: There's substantial discussion about solar energy development and offshore wind parks. The conversation highlights how renewable energy production has scaled dramatically while costs have fallen significantly over time.

- Oil Companies' Green Transformation: British Petroleum (BP) attempted to rebrand itself as "Beyond Petroleum," showing the oil industry's recognition of the need to transition. The podcast discusses how large multinationals are adapting to changing energy landscapes.

- Regional Energy Cooperation: The concept of "Europa+" is mentioned, referring to an energy cooperation framework between Europe, the UK, and North Africa. Morocco and other North African countries are highlighted as potential partners in renewable energy development.

- Hydrogen Economy Development: Hydrogen is discussed as a key component of the future energy system, with mentions of hydrogen markets and infrastructure being developed. This includes projects like "Magnum" that are advancing hydrogen technologies.

- Brussels as a Regulatory Force: The podcast describes Brussels as a complex regulatory machine that creates frameworks like the taxonomy system, which defines sustainable economic activities. These regulations are shaping how businesses and countries approach the green transition.

- Political Challenges to Green Policies: The European Green Deal is facing opposition from right-wing political groups. The conversation explores whether Europe can still become a "green superpower" despite these political headwinds.

- Energy Security Concerns: Winter energy supply challenges in Europe, particularly in the Netherlands, are discussed. The conversation touches on seasonal variations in renewable energy production and the need for reliable energy systems.

- Industrial Transformation: Various sectors including automotive and cement production are undergoing green transformations. The podcast notes that these transitions cannot happen instantly (not "100 percent") and require careful planning and implementation.
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Each episode, Dan and Jordan take a look at some clips from that day's Alex Jones Show and struggle to make sense of what they find.

#1097: November 15, 2025

Knowledge Fight

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The Marjorie Taylor Greene-Trump Conflict: Dan and Jordan discuss the emerging conflict between Trump and MTG over the Epstein files. Trump called her "Marjorie Taylor Brown" (saying "grass turns brown when it rots") and threatened to support primary challengers against her after she advocated for releasing Epstein documents. Alex Jones acknowledges that Trump "looks guilty" in his response but tries to deflect blame.

Alex's Deflection Strategies: Throughout the episode, Alex employs various deflection tactics when confronted with Trump's problematic behavior. When reading MTG's texts and Trump's response on air, he realizes the situation makes Trump look bad, so he suddenly pivots to ranting about Lindsey Graham and South Park to distract his audience from the uncomfortable implications.

Trump's Cover-Up Involvement: Alex admits that Trump appears to be participating in a cover-up regarding the Epstein files, claiming "billionaires came to him" and convinced him to participate. Despite acknowledging this, Alex still maintains overall support for Trump, characterizing the situation as just throwing out "the bathwater, not the baby."

Alex's Contradictory Principles: Dan points out that Alex previously criticized "unelected bureaucracy" influencing presidents, but now suggests Trump should listen to billionaires and advisors like Elon Musk. This reveals that Alex's complaints about "elites" were never sincere but were socially acceptable ways to attack the system without revealing his true priorities.

The Epstein Files Controversy: The hosts discuss recently released emails showing Steve Bannon and Jeffrey Epstein communicating in 2018 about creating a documentary to rehabilitate Epstein's image. Alex dismisses these damning connections, claiming nothing significant has been revealed in the documents so far.

Alex's Diminishing Relevance: Dan observes that Trump doesn't attack Alex the way he attacks MTG because Alex is irrelevant to Trump's power structure. While MTG has political influence worth responding to, Alex has no leverage, having compromised his principles to support Trump regardless of his actions.

Alex's Business Dynamics: During a product advertisement, Alex mentions two different websites where listeners can purchase his products (RealAlexJones.com and AlexJonesStore.com), suggesting he might receive different commission rates from each site, as he directs listeners specifically to RealAlexJones.com.

Bioweapon Conspiracy Claims: Alex promotes a conspiracy theory about bioethicists planning to make humans allergic to meat using technology related to the Lone Star tick, claiming this is part of a climate change agenda. He distorts the context of a bioethicist discussing theoretical possibilities to make it sound like an active plan.

The "MAGA Civil War": Alex frames the conflict between Trump and his former allies as a "MAGA civil war" but insists that populism will continue with or without Trump. This serves as a hedge while still maintaining overall support for Trump.

Alex's Inevitable Breaking Point: Dan and Jordan discuss how Alex's attempts to rationalize Trump's behavior are becoming increasingly difficult and predict that eventually, his support will become untenable as Trump continues to attack people who were once considered allies in the fight against "globalists."
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In Rusty's Garage, automotive commentator and journalist Greg Rust speaks to the most passionate riders, drivers, designers and collectors he knows. Each guest shares their stories about the machines they've owned, raced, crashed &amp; restored throughout their lives going flat out.

The Motorsport Brief | Supercars Grand Final preview with Thomas Randle

Rusty's Garage

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- Thomas Randle's UK Adventure with Rally Legends: Thomas recently returned from a whirlwind trip to the UK, where he participated in a Castrol filming day at M Sport in Cumbria. He had the opportunity to meet and drive with rally legends Carlos Sainz Sr. and Petter Solberg. Highlights included being taken for hot laps by Sainz in his 2026 Dakar T1 Ford Raptor and a WRC car, before driving the WRC car himself on narrow gravel roads.

- Supercars Finals Format: Thomas discusses the new finals format in Supercars, noting that while he's disappointed not to make the Final Four, he believes the format has increased intensity and created compelling storylines. He mentions how competitive the season has been, with qualifying at Bathurst seeing the top 10 separated by just two-tenths of a second.

- Adelaide Grand Final Preview: The Adelaide 500 serves as the season finale with 50 points separating the top four drivers and 300 points on offer. Thomas highlights how unpredictable the event could be, especially with challenging sections like Turn 8 that can easily end a driver's race. He expects Sunday's final race to be particularly exciting as drivers with nothing to lose push the limits.

- Austin Cindric's Wildcard Entry: NASCAR driver Austin Cindric is participating as a wildcard in Adelaide with Tickford Racing. Thomas describes Cindric as dedicated and eager to learn, noting how they've been helping him adjust to Supercars terminology and procedures. They spent hours in the simulator preparing for Adelaide, and Thomas expects Cindric to perform well despite the challenges.

- Tribute to Allan Moffat: Thomas reflects on the passing of motorsport icon Allan Moffat, recognizing his significant contributions to Australian and global motorsport. He acknowledges Moffat's struggle with dementia over the past six years and expresses hope that Supercars will honor his legacy during the Adelaide weekend.

- Formula One Championship Battle: When asked about the F1 championship, Thomas notes the close battle between Lando Norris and Max Verstappen. He points out how McLaren's double disqualification and Verstappen's resurgent form have put pressure on Norris, suggesting the championship could easily swing either way in the final races.

- Adelaide's Racing Heritage: Thomas discusses Adelaide's 40-year history of street racing, including its Formula 1 past from 1985-1995. He praises the current South Australian government for bringing back the race and investing heavily in its promotion, describing it as drivers' favorite track outside of Bathurst.
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The Shotgun Start with Andy Johnson and Brendan Porath of Fried Egg Golf is a podcast waiting for you early in the morning that quickly blasts through a variety of topics (usually) related to golf and (ideally) relevant to the day. It covers news from the pro tours around the world, amusing and important topics from the amateur game the rest of us play, and some irreverent stuff in between. There will be short interviews, previews, reviews, and dives into the archives. It provides what you need to know on golf through a rapid and fun catch-up discussion.

The 2025 Year in Review, Part 2

The Shotgun Start

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TGL Hijacks the Year-in-Review: A significant portion of this episode focused on TGL (Tiger Woods and Rory McIlroy's tech-infused golf league) moments, particularly Billy Horschel's debut with the Atlanta Drive where he embraced his role with the "Dirty Birds" chain and dance, helping lead the team to victory over NY Golf Club. Tiger Woods notably received the only shot clock violation of the year, and the hosts reminisced about their visit to the "Sofi Dome" in Palm Beach.

Farmers Insurance Open at Torrey Pines: The tournament suffered from numerous withdrawals including Will Zalatoris, Collin Morikawa, and Xander Schauffele, resulting in the weakest field in 30 years. Harris English won his fifth PGA Tour event with a steady performance, making 15 pars in his final round including nine straight on the back nine to close out the victory.

Rory McIlroy Wins at Pebble Beach: Rory captured his 27th PGA Tour victory at the AT&T Pebble Beach Pro-Am, highlighted by an incredible 65 in difficult windy conditions on Saturday. His eagle on the 14th hole on Sunday effectively sealed his win. Afterward, Rory noted he was trying to play "more boring like Scottie" and expressed satisfaction in winning at what he called "one of the cathedrals of the game."

Scottie Scheffler's Hand Injury Mystery Solved: The world's top player finally revealed that his hand injury from earlier in the year resulted from attempting to roll pasta with a wine glass that broke. Scheffler returned at Pebble Beach, finishing T9 and leading the field in strokes gained approach despite the layoff.

PGA of America Leadership Drama: Seth Waugh took credit for suggesting Keegan Bradley as Ryder Cup captain and stated he wouldn't have paid Ryder Cup players. Meanwhile, his successor Derek Sprague took a staunchly anti-rollback stance on golf ball regulations, claiming it would be difficult for PGA professionals to enforce at the recreational level.

The Broadcasting Gap Continues: During Rory's crucial play on holes 7 and 8 at Pebble Beach, CBS switched to a college basketball game between Illinois and Ohio State, forcing viewers to watch online and missing part of the action from one of the most picturesque holes in golf.

Bryson DeChambeau in India: While the PGA Tour's signature event was happening at Pebble Beach, Bryson was playing the DLF in India, where he called the course "diabolical" and strategic. He also expressed interest in the Crushers team potentially playing in TGL, though acknowledging he didn't know if it would "make me enough money."

Jim Nantz Buys Scottie Scheffler's Truck: In an unusual news item, CBS broadcaster Jim Nantz purchased Scottie Scheffler's 2012 GMC Yukon with over 150,000 miles on it for $50,000 at an auction.
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Since 1994, this daily broadcast has provided accessible, in-depth Bible teaching to millions around the world. As the principal outreach of Ligonier Ministries, it has instructed listeners in the life-changing truths of historic Christianity and has kept the church community informed about pertinent issues facing believers today.

Psalm 32: The Joy of Forgiveness

Renewing Your Mind with R.C. Sproul

Renewing Your Mind

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- The Blessing of Forgiveness: Every Christian is someone whose sins have been forgiven. To enter into a reconciled relationship with God is to enter a state of blessedness. We are blessed not because we are righteous, but because we are forgiven.

- David's Psalm 32: After exploring repentance in Psalm 51, R.C. Sproul examines Psalm 32, where David expresses the joy of forgiveness. David pronounces a blessing on those whose transgressions are forgiven and whose sins are covered. This psalm is quoted by Paul in Romans as he explains the gospel.

- The Concept of Imputation: At the heart of the gospel is imputation—the legal transfer of accounts. In the cross, our sins are imputed to Christ as our substitute. Conversely, His righteousness is imputed to our account. David describes this as "blessed is the man to whom the Lord does not impute iniquity."

- The Dark Night of the Soul: David describes his experience before confession as a time when God's hand was "heavy upon him." He uses drought imagery to portray his spiritual dryness when he kept silent about his sin. His "vitality was turned into the drought of summer" and his "bones grew old" from the weight of unconfessed sin.

- The Relief of Confession: When David finally acknowledged his sin to God and confessed his transgressions, God forgave the iniquity of his sin. This pattern of confession leading to forgiveness is fundamental to the Christian experience.

- God as Our Hiding Place: After experiencing forgiveness, David describes God as his "hiding place" who preserves him from trouble. Using flood imagery (contrasting with the earlier drought metaphor), David explains how God protects the forgiven person from overwhelming circumstances.

- The Joy of Restoration: The psalm concludes with a call to "be glad in the Lord and rejoice." David, who had earlier cried out in pain and groaned in misery, now shouts with joy because the bones "which the Lord had broken are once again rejoicing." God has restored to David the joy of his salvation, which is the experience of every Christian who has known true forgiveness.
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From the construction of virtual realities to the internet of things—technology is changing our world every day. But how can we make sure that the quickly-evolving role that tech plays in our lives is one that builds, empowers, and connects us? Host Sherrell Dorsey guides you through the latest ideas from TED Speakers, uncovering the riveting questions that sit at the intersection of technology, society, science, design, business, and innovation. Listen in every Friday.

Tech Solutions (#4): How organizations can grow in a post-aid world (with Jacqueline Novogratz)

TED Tech

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- Shifting from Aid to Agency: Jacqueline Novogratz, founder and CEO of Acumen, explains that the dismantling of USAID has triggered a shift toward a "post-aid era." Rather than seeing this as a complete loss, she views it as an opportunity to develop more creative approaches to funding that foster independence and dignity at community and company levels instead of creating dependency.

- Acumen's Mission and Approach: Acumen uses market tools to create solutions to poverty while building a world of dignity. The organization has steered over $500 million toward businesses tackling poverty and climate injustice, reaching more than 650 million people. Their approach includes selecting entrepreneurs with the right character and measuring impact from the perspective of people being served through bottom-up methods rather than top-down monitoring.

- Rejecting False Binaries: Novogratz advocates for nuance in the climate conversation, rejecting the false binary between mitigation and adaptation. For communities without electricity, adaptation solutions (like off-grid solar) provide immediate benefits while also contributing to long-term mitigation goals. She also challenges the notion that pure market capitalism is the answer for all climate tech, noting that creative financing models are needed for technologies serving low-income markets.

- Innovative Financing Models: For entrepreneurs serving people earning $1-3 per day, traditional financing doesn't work. Acumen employs blended capital approaches, including currency swaps for companies operating in countries with unstable currencies. In Malawi, they worked with an entrepreneur named Maya who runs Yellow, a solar company, using creative financing and "results-based financing" from the World Bank to serve the poorest communities.

- Elevating Local Solutions: Some of the most innovative entrepreneurs come from the communities they serve, including those who grew up in refugee camps. Novogratz emphasizes that these local entrepreneurs bring vital understanding through "moral imagination" that requires immersing in and listening to the people they want to serve. However, they often lack the social capital and connections needed to access investment.

- Promising Climate Technologies: The most exciting climate technologies are those useful to low-income people. Examples include biodigesters that convert cow waste into cooking fuel and fertilizer, and S4S in India, which provides solar dryers to women entrepreneurs who help smallholder farmers preserve their produce, reducing waste and transport emissions while creating a more inclusive supply chain.

- Patient Capital and Social Support: Building markets that have never existed before requires investors willing to be patient through inevitable challenges. During COVID-19 and currency crises, Acumen created emergency support vehicles to help companies survive. Beyond financial capital, social capital is crucial - helping entrepreneurs make connections with government officials or other stakeholders that can overcome regulatory hurdles.

- Business as Nation Building: When companies solve significant problems of poverty, they also help build nations by creating jobs and opportunities. Cook stove company Burn employs over 2,000 people in local manufacturing, with thousands more indirect jobs through agents and entrepreneurs who use their products. This demonstrates how business can be a powerful vehicle for sustainable development.
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Over 12,000 people per day, from all over the world have found the Morning Mindset a great, Jesus-filled way to help them get their minds aligned with the truth of God's word, every single morning! Episodes are drawn directly from scripture, life-application-based, steeped in prayer, and challenging to mature and beginning Christ-followers alike. 7 minutes to get your day started with Jesus!&nbsp; Find out more at <a href="http://YourMorningMindset.com">http://YourMorningMindset.com</a> or become a monthly partner and get access to our Partners-only podcast feed of bonus material at <a href="https://MorningMindsetMedia.com/partner">https://MorningMindsetMedia.com/partner</a>. Contact Carey at <a href="mailto:admin@morningmindsetmedia.com">admin@morningmindsetmedia.com</a>&nbsp;

God could be against you (1 Peter 5:5-7) : Christian Daily Devotional Bible Study and Prayer

Morning Mindset Christian Daily Devotional Bible study and prayer

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- God's Opposition to the Proud: Based on 1 Peter 5:5-7, there are circumstances where God could legitimately be against believers. This occurs specifically when Christians become proud, as "God opposes the proud but gives grace to the humble." To oppose means to be an adversary or opponent, suggesting God actively positions Himself against those who exhibit pride.

- Pride as the Original Sin: Pride is identified as the fundamental sin that caused Lucifer's fall from heaven and Adam and Eve's disobedience in Eden. When believers become proud, they essentially repeat this original sin pattern, thinking their way is better than God's way.

- The Right Posture Before God: Humility represents the proper position for humans as creatures under the rule of their Creator. When believers humble themselves under God's hand, they align with their created purpose and position themselves to receive God's grace and help.

- God's Opposition as Loving Correction: When God opposes the proud, He does so for their benefit. This opposition is not punitive but redemptive—designed to bring believers back to a posture of humility where they can again receive His grace.

- Practical Application: The devotional encourages listeners to recognize pride in themselves, repent of it, and ask God for the grace to live with genuine humility. This involves rejecting arrogance and acknowledging that God alone is worthy of exaltation.
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The Cabral Concept by Dr. Cabral was created for you, the health conscious individual looking to discover the little known factors to ideal wellness, weight loss, and anti-aging. We uncover the root causes of why you're feeling stuck and unable to attain your goals and the action steps needed to live the life you always dreamed of. Plus, every day I answer your natural health wellness, weight loss, mindset, product review, and longevity questions. By following the Cabral Concept of "Change Your Body - Change Your Life," our community believes that by first rebalancing your body and mind, you will then be motivated to conquer any goals you set for yourself in life. I look forward to sharing these real world, proven, holistic strategies with you straight from my Boston Naturopathic, Ayurvedic, and Functional Medicine practice!

3584: Beacon40, Artificial Sweeteners & AFib Risk, Blood Markers & Depression Link (FR)

The Cabral Concept

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- Beacon 40 Device for Brain Health: A new health tech product that uses 40 Hz flickering light technology to improve focus and memory formation by 48%, boost mood by 46%, and reduce stress by 40%. The device is passive - you simply keep it on your desk or in your space for 20-30 minutes daily without directly staring at it. Studies also show it may help stave off dementia and Alzheimer's by affecting gamma waves in the hippocampal part of the brain.

- Artificial Sweeteners Linked to Heart Issues: A study of 202,000 adults published in the Circulation, Arrhythmia and Electrophysiology Journal found that consuming just 8-9 ounces of artificially sweetened beverages daily (2 liters per week) increased the risk of atrial fibrillation by 20%. This irregular heartbeat is linked to stroke risk, suggesting natural sweeteners like maple syrup, raw honey, stevia or monk fruit may be better alternatives.

- Blood Markers Predict Future Mental Health: Research from Stockholm involving 211,000 adults showed that people with high blood sugar and high triglycerides in their 40s were more likely to experience chronic stress and mood disorders (including depression) in their 60s. Conversely, those with high levels of "good" cholesterol in their 40s had better mental health outcomes later in life.

- Inflammation's Body-Wide Impact: The connection between blood markers and mental health highlights how inflammation affects the entire body, not just specific organs. Rather than treating symptoms with medications like statins for high cholesterol, addressing the root causes of inflammation may prevent both physical and mental health issues later in life.

- Weekly Episode Recap: This Friday Review episode referenced earlier shows from the week covering how thoughts influence reality, natural methods to lower ApoB cholesterol, the most inflammatory foods, and whether melatonin poses heart risks.
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Welcome to the official Labiotech.eu podcast - Beyond Biotech! Each week, we talk about what's happening in the world of biotech, with news and interviews with experts from companies around the world. Join us as we cover the latest news, breakthroughs and innovations shaping the life sciences industry.A new podcast episode is available every Friday. The host is Dylan Kissane.

Curing cancer: Daiichi Sankyo's ambitious ADC approach

Beyond Biotech - the podcast from Labiotech

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- From Physician to Pharmaceutical Leader: Dr. Markus Kosch, Head of EU Oncology Business Division at Daiichi Sankyo, was drawn to oncology early in his medical career. After his father died of cancer during his late teenage years, he was motivated by the urgent medical needs in this field. His 10 years of clinical experience at a university hospital setting has shaped his patient-centric approach in his current role, giving him firsthand understanding of patient needs and credibility with healthcare professionals.

- Daiichi Sankyo's Evolution in Oncology: While Daiichi Sankyo is a 120-year-old Japanese company with a long research legacy, its full focus on oncology began just 10-15 years ago. The company's breakthrough came with its antibody-drug conjugate (ADC) platform, leading to the creation of a dedicated oncology business unit five years ago. Despite being headquartered in Tokyo, the company has made significant investments in Europe, including its European headquarters in Munich and a €1 billion manufacturing facility in Pfaffenhofen.

- The ADC Platform Advantage: Daiichi Sankyo's ADC platform represents a technological breakthrough in cancer treatment. These antibody-drug conjugates combine a highly specific antibody with a toxic chemotherapeutic agent (warhead) that would be too toxic for systemic administration. Their unique approach includes a warhead that degrades quickly after killing cancer cells, a specific linker that enables the "bystander effect" (allowing the toxin to move between cells), and a payload that causes specific tumor DNA damage. These technical advantages have translated to superior clinical outcomes.

- Impressive Clinical Trial Results: Recent data presented at ESMO shows remarkable efficacy across multiple trials. In breast cancer, their Her2-directed ADC showed progression-free survival of 16 months in later-line treatment, improving to 28 months in second-line, and more than 40 months in first-line treatment. Their triple-negative breast cancer trials marked the first overall survival improvement in a decade. Six out of seven pivotal trials released this year showed positive results, demonstrating the platform's consistent efficacy.

- Managing Complexity Through Partnerships: To manage an extensive clinical development program (over 60 trials across 24 countries), Daiichi Sankyo relies on strategic partnerships with companies like AstraZeneca and Merck. These collaborations allow them to expand their regional footprint, accelerate clinical trials, and enhance resources. Their partnership with AstraZeneca in developing Her2-directed therapies has been particularly successful, revolutionizing breast cancer treatment by expanding therapy eligibility to approximately 90% of breast cancer patients.

- Patient-Centricity and External Innovation: Patient advocacy groups play a crucial role in Daiichi Sankyo's approach to trial design and therapy development. The company actively involves patient representatives when designing trials, developing therapies, mitigating side effects, and discussing market access policies. Their open innovation strategy also includes collaborations with academic institutions like MD Anderson and the Sarah Connor Research Institute, as well as biotechs and research consortia to accelerate target exploration and technology development.

- Future Vision for Oncology: Kosch is optimistic about oncology's future, envisioning cancer becoming a chronic or even curable disease for many patients within the next decade. He sees ADCs as the third major wave of cancer innovation, following targeted therapies (TKIs) and immunotherapies (checkpoint inhibitors). With their deep and long-lasting responses, ADCs have the potential to address unmet needs across multiple cancer types and meaningfully change treatment algorithms.
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A daily news podcast, The Briefing gives you the latest headlines, discussion and explainer interviews, all in under 20 minutes. Bringing you the news you need to know at 6am and 3pm Monday to Friday, and profiles across the weekend, The Briefing is Australia's go-to news podcast for your commute, coffee or exercise.
Hosted by a cast of rotating journalists including Sacha Barbour-Gatt, Katrina Blowers, Antoinette Lattouf, and Bension Siebert.

Man shot dead in suburban street + Lifesaving importance of blood donors

The Briefing

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- Sydney Shooting Incident: Two people have been arrested after a man in his 20s was shot dead on a residential street in Sydney's West. The shooting occurred in Blacktown around midday, with the victim suffering multiple gunshot wounds. The suspects fled in a ute before being apprehended after a police pursuit.

- White House Security Incident: National Guard member Sarah Bechstrom has died after being shot near the White House in what authorities described as an ambush-style attack. Another guard, Staff Sergeant Andrew Wolf, remains in critical condition. The alleged shooter, a 29-year-old Afghan national, is in custody and also in critical condition.

- Seafood Shortage Warning: Shoppers are being warned about higher prawn prices this Christmas due to low stocks. Fishers in Queensland and New South Wales report below-average hauls of tiger, endeavour, and king prawns due to cooler temperatures and challenging weather conditions.

- Rosie's Rare Blood Disorder: 11-year-old Rosie was diagnosed with aplastic anemia, a rare form of bone marrow failure that prevents her body from producing red blood cells, white blood cells, and platelets. This life-threatening condition has left her with severely compromised immunity, extreme fatigue, and a constant risk of dangerous bleeding.

- Critical Importance of Blood Products: Since her diagnosis in February, Rosie has relied on regular blood and platelet transfusions to survive. She requires platelets weekly or twice weekly to prevent life-threatening bleeding, as her platelet count can drop to dangerous levels (under 10, when normal is 150,000). Her hemoglobin levels also drop to 60-70 without transfusions (normal range is 120-160).

- Impact on Daily Life: Rosie described how her condition has severely limited her activities, making even simple tasks like taking a short walk or going out for coffee extremely tiring. The family has faced numerous emergency hospital visits when Rosie's condition deteriorated suddenly.

- Call for Blood Donors: Australia needs a new blood donor every five minutes, but only one in 30 Australians donate. Rosie and her mother emphasized that blood donation is a life-saving gift, especially needed during the holiday season when supplies are at concerning lows. They expressed deep gratitude to anonymous donors whose generosity has kept Rosie alive while she awaits a bone marrow transplant.
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